Melissa encompasses approximately seven square miles with a terrain with rolling hills situated between the East fork of the Trinity River and Sister Grove Creek. The City of Melissa is located a short distance from two popular Texas lakes, Lake Lavon and Lake Texoma.

Making easy access for travel in all directions, Melissa has three intersecting highways. Highway 75 and Highway 5 (McKinney Street) provide easy access south to Dallas, Austin and San Antonio, and north to Oklahoma. Highway 75 also intersects with Interstate 635, the major business loop around Dallas. State Highway 121 runs northeast and southwest providing access south to DFW International Airport and south to the Dallas North Tollway.

DFW International Airport is the world's third busiest, offering nearly 2,000 flights per day and serving 54 million passengers a year. DFW International Airport provides non-stop service to 132 domestic and 30 international destinations worldwide.